COA: Use of rhPDGF in a collagen matrix effective for foot and ankle fusion .
Outcomes of Hindfoot and Ankle Fusions Treated with Augment Injectable Bone Graft: Results of a Prospective Randomized Controlled Trial
217 patients undergoing hindfoot and ankle reconstruction were randomized to receive either the Augment Injectable Bone Graft, containing platelet-derived growth factor (rhPDGF-BB in a tricalcium phosphate (B-TCP)/collagen matrix, or an autogenous bone graft to compare bone fusion and clinical success rates. Patients were to be assessed over a 1 year period; preliminary results indicated that fusion and clinical success rates were significantly higher in the group of patients who received rhPDF-BB in a collagen matrix during surgery, compared to patients who received the autogenous bone graft.
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