330 patients requiring ACL reconstruction were randomized to undergo the procedure using either a double-bundle hamstring tendon autograft (DB group), a quadruple-stranded hamstring tendon autograft (HT group) or a patellar tendon autograft (PT group). The purpose of this study was to compare these two treatment approaches with respect to rate of re-injury and quality of life at 2 years postoperatively. Results indicated that all three groups yielded statistically similar scores for quality of life. Although younger age and Tegner activity levels at 2 years were found to be significant predictors of complete traumatic re-ruptures and traumatic re-injuries, this was irrespective of graft type used. There were no significant predictors for atraumatic graft failure.