Capsaicin provide comparable or better pain and functional improvement than placebo .
Capsaicin instillation for postoperative pain following total knee arthroplasty: a preliminary report of a randomized, double-blind, parallel-group, placebo-controlled, multicentre trial
Clin Drug Investig. 2011 Dec 1;31(12):877-82. doi: 10.2165/11593860-000000000-0000016 patients were randomized to examine whether direct instillation of a capsaicin preparation into the wound after total knee arthroplasty (TKA) would improve clinical outcomes. Patients received either 5 mg capsaicin, or 15 mg capsaicin, or a placebo and were assessed after the first 24 hours and then daily for 3 days. Results revealed that the capsaicin groups produced comparable or better pain scores with significantly less opioid use when compared to the placebo group.
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