Canakinumab effective in treating systemic juvenile idiopathic arthritis .
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Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis
N Engl J Med. 2012 Dec 20;367(25):2396-406. doi: 10.1056/NEJMoa1205099177 patients, suffering from systemic juvenile idiopathic arthritis (JIA) with active systemic features, who had been chosen to participate in two trials between July 2009 and December 2010, were randomised into two groups to either receive canakinumab or a placebo. Patients in Trial 1 received either canakinumab or the placebo for 29 days. Trial 2 incorporated a two-part withdrawal design, which consisted of an open-label phase, lasting for 32 weeks, and a withdrawal phase. The results demonstrated that the canakinumab was effective in treating systemic JIA following a 29 day and 32 week follow-up period, but had potential to occasionally cause infections.
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