Bone morphogenetic protein-2 against iliac crest bone graft for the posterolateral fusion of the lumbar spine: A meta-analysis
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(12):22 Int J Clin Pract. 2021 Apr;75(4): e13911.What this means for my practice?
The results of this meta-analysis suggest that bone morphogenetic protein-2 treatment can significantly improve fusion rate and functional outcomes, as well as reduce operative time, blood loss and the need for secondary surgery when compared to iliac crest bone grafting in patients undergoing posterolateral fusion of the lumbar spine. This study was limited by the inclusion of only English studies, as well as the lack of subgroup analyses by gender and ethnicity. Future studies comparing the effectiveness of the two treatments in different ethnicities and genders are of interest.
Study Summary
Fourteen studies with a total of 1516 patients undergoing posterolateral lumbar spine fusion were included in this meta-analysis comparing iliac crest bone grafting (n=727) to bone morphogenetic protein-2 (n=789). Pooled outcomes of interest included the rate of fusion, rate of non-union, operative time, blood loss, length of stay, need for secondary surgery, Oswestry Disability Index (ODI) scores, and the incidence of adverse events. Pooled results of this meta-analysis demonstrated significantly higher fusion rates, shorter operative time, lower blood loss, reduced need for secondary surgery, and better ODI scores in the bone morphogenetic protein 2 group compared to the iliac crest bone grafting group (p<0.05 for all). No significant differences in pooled non-union rate, length of stay, or adverse event rate were observed between the two groups (p>0.05 for all).
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
