Beneficial effect on pain & ROM with periarticular multimodal drug injection in TKA & THA .
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The efficacy of periarticular multimodal drug injection for postoperative pain management in total knee or hip arthroplasty
J Arthroplasty. 2013 Dec;28(10):1882-7. doi: 10.1016/j.arth.2013.06.031. Epub 2013 Aug 121 randomized controlled trials were included in this meta-analysis which investigated the use of periarticular multimodal drug injection (PMDI) as a method of postoperative analgesia in total knee and total hip arthroplasty. Outcomes of interest included pain, opioid requirements, range of motion, length of hospital stay, and incidence of adverse events. The pooled results indicated that immediate postoperative pain was reduced with PMDI; however, significance began to be lost in the later postoperative period (24h and 48h). PMDI also had a significant effect on the reduction of opioid requirements and improvements in range of motion.
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