Assessment of IV, IA, and oral tranaexamic acid safety in total joint arthroplasty .
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The Efficacy of Tranexamic Acid in Total Hip Arthroplasty: A Network Meta-analysis
J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.02378 randomized controlled trials were included in this meta-analysis, which sought to evaluate the incidence of venous and arterial thromboembolic (VTE and ATE) events associated either intravenous, intraarticular, and oral tranexamic acid, and compare rates to placebo or control intervention groups. No analysis demonstrated a significant increase in the risk of VTE or ATE complications with either intravenous TXA, intraarticular TXA, or oral TXA.
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