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The use of IA-HA injections is inappropriate for symptomatic adults who have active local or intra-articular infection of the knee. The use of IA-HA injections is uncertain in symptomatic adults with severe OA who have not received, incomplete, failed or are intolerant to other therapies for the knee. It is also uncertain whether IA-HA is beneficial for individuals with mechanical meniscus pathology, active inflammatory arthritis, synovitis of the knee or who are at high risk of adverse reaction to HA or pharmacological agents for the knee. The use of IA-HA injections is appropriate for symptomatic adults with mild to moderate OA who have not received, incompleted, failed or are intolerant to other therapies for the knee.