Significant Anxiolytic Effect and Enhanced Recovery Benefits of Perioperative Low-Dose Olanzapine in Patients with Anxiety Undergoing THA: A Randomized Controlled Trial.

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

135 patients with hip osteoarthritis and clinically important anxiety symptoms undergoing primary total hip arthroplasty (THA) were randomized to receive perioperative low-dose olanzapine (2.5 mg), alprazolam (0.4 mg), or placebo. The primary outcome was anxiety severity, measured using the State-Trait Anxiety Inventory-State (STAI-S). Secondary outcomes included sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI), pain measured using the visual analogue scale (VAS), opioid consumption, postoperative nausea and vomiting, and hip function assessed using the Harris Hip Score (HHS) and Hip Disability and Osteoarthritis Outcome Score (HOOS). Outcomes were assessed up to 24 weeks postoperatively. Overall, the results of the study revealed that olanzapine significantly reduced early postoperative anxiety, pain, opioid consumption, and nausea and vomiting while improving sleep quality and functional recovery compared with placebo, with greater early anxiolytic benefits than alprazolam. These findings suggested that short-term, low-dose olanzapine could improve perioperative recovery in patients with anxiety undergoing THA.