Anti-inflammatory effects of intra-articular hyaluronic acid: A systematic review
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(22):18 Cartilage. 2018;10(1):43-52What this means for my practice?
HA produces molecular weight–dependent anti-inflammatory effects through a multifactorial mechanism of action via CD44, TLR, and I-CAM receptor signaling. High molecular weight HA combats the pro-inflammatory influences of fragmentized HA.
Study Summary
Forty-seven non-clinical, basic science articles describing the anti-inflammatory mechanism of hyaluronic acid (HA) treatment for osteoarthritis (OA) were included in this systematic review. The key findings were summarized based on the categorical inflammatory response; categories included HA-CD44, HA-TLR-4, HA-LAYN, and HA-ICAM-1 receptor responses.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
