Annual infusion of zoledronic acid reduces days of back pain, disability, and bed rest .
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Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture Trial
J Bone Miner Res. 2011 May;26(5):984-92. doi: 10.1002/jbmr.292In a secondary prespecified analysis, 7736 postmenopausal women with osteoporosis were examined to evaluate the effect of once-yearly zoledronic acid on improving back pain and disability. Patients received either a single 15 minute intravenous fusion of zoledronic acid (5 mg) or placebo at baseline, 12 months, and 24 months. The assessment at 36 months indicated that zoledronic acid significantly reduced the number of days with back pain when compared to placebo. Additionally, zoledronic acid reduced the number of days of limited activity due to back pain and limited activity and bed rest after a fracture.
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