Efficacy and Safety of Morphine and Low Dose Ketamine for Pain Control of Patients with Long Bone Fractures: A Randomized, Double-Blind, Clinical Trial

159 patients with a long bone fracture and presenting to the emergency department were randomized to analgesia with either intravenous low-dose ketamine or intravenous morphine,. Patients were assessed over the first 240 minutes after administration for pain scores and adverse events. There were no significant differences between the two groups in Numeric Rating Scale pain scores at 30, 60, 90, 120, 180, or 240 minutes after administration. There were also no significant differences between the two groups in the incidence of adverse events.