Alendronate improves bone mineral density after total knee arthroplasty .
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The effect of alendronate on bone mineral density in the distal part of the femur and proximal part of the tibia after total knee arthroplasty
J Bone Joint Surg Am. 2003 Nov;85-A(11):2121-696 women undergoing total knee arthroplasty were randomized to receive oral alendronate at a dose of 10 mg/day for six months, or not. The bone mineral density in the distal part of the femur and proximal part of the tibia was determined preoperatively and at 6 and 12 months postoperatively. Significant decreases in density were seen in the control group at 6 and 12 months, though patients receiving alendronate experienced significant improvement in bone mineral density.
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