Thirty patients with incomplete spinal cord injuries were randomized to receive 4 weeks of photobiomodulation and physiotherapy treatment or sham photobiomodulation and physiotherapy for the improvement of sensory-motor function and quality of life. The primary outcome of interest was the sensitivity and motor assessment via the American Spinal Injury Association (ASIA) Impairment Scale. The secondary outcome of interest was quality of life measured with the World Health Organization Quality of Life BREF (WHOQOL-BREF) questionnaire. Outcomes were assessed at baseline, upon completion of treatment, and 30 days post-treatment. An improvement in light touch sensation, pin prick sensation, and muscle strength was observed after treatment in the active photobiomodulation group. The sham group reported no significant improvements in sensory-motor function. A statistically significant difference in WHOQOL-BREF social relationship and general domain scores was observed in the active photobiomodulation group compared to the sham group after treatment (p<0.05 for both).