Aceclofenac & Ilaprazole vs Celecoxib for NSAID-Induced Dyspepsia in Lumbar Spinal Stenosis Patients .
Efficacy of Aceclofenac and Ilaprazole Combination Therapy versus Celecoxib Monotherapy for Treating NSAID-Induced Dyspepsia in Lumbar Spinal Stenosis Patients.
Medicina (Kaunas). 2023 Jul; 59(7): 1307.128 patients with lumbar spinal stenosis who were receiving continuous non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) were randomized to receive either a COX-2 selective NSAID (celecoxib; n=64) or a combination of an NSAID (aceclofenac) and a proton pump inhibitor (ilaprazole) (n=64). The primary outcome of interest was the severity of dyspepsia, as measured by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ). The secondary outcomes of interest included quality of life (Short Form 12 [SF-12]) and the incidence of adverse events. The results of this study found no significant difference between the two groups. This suggests that the combination of aceclofenac and ilaprazole does not provide any advantage over COX-2 selective NSAIDs for the mitigation of dyspepsia in lumbar spinal stenosis patients.
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