SPORTS MEDICINE
Accelerated weightbearing rehabilitation after matrix-induced autologous chondrocyte implantation in the tibiofemoral joint: early clinical and radiological outcomes
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2014;2(1):26 Am J Sports Med. 2013 Oct;41(10):2314-24Exclusive Author Interview
Dr. Ebert discusses how accelerated weightbearing rehabilitation can affect outcomes after matrix-induced autologous chondrocyte implantation.
A total of 26 patients (28 knees), who had undergone matrix-induced autologous chondrocyte implantation to treat full-thickness femoral condylar defects in the knee, were randomly assigned into 1 of 2 groups to test the effectiveness of an accelerated weight-bearing protocol following surgery. Patients either received a weight-bearing protocol that aimed to achieve maximum weight bearing by 6 weeks (accelerated) or 8 weeks. Results indicated that the accelerated weight-bearing protocol improved physical function and quality of life, and achieved earlier attainment of full active knee extension than conventional weight-bearing regimens.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
はい = 1
不確実＝0.5
無関係 = 0
いいえ = 0
報告基準評価では、著者が出版物内で試験の方法論的特徴や試験特性を報告する際の透明性を評価します。評価は以下の5つのカテゴリーに分類されます。
4/4
Randomization
3/4
Outcome Measurements
4/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Fragility Indexは、重要な所見の解釈を助けるツールで、結果の強さの尺度を提供します。Fragility Indexは、その所見が有意でなくなるために、二項対立の結果に追加する必要がある連続した事象の数を表します。数値が小さいほど弱い所見を表し、数値が大きいほど強い所見を表します。
なぜ今この研究が必要なのですか？
Matrix-induced autologous chondrocyte implantation (MACI) is an effective way to repair full-thickness chondral defects in the knee. Successful cell culturing, efficiency of the surgical procedure, patient cooperation, and timely weight-bearing are all key factors that play a role in the effectiveness of treatment. Studies have proposed that more aggressive and accelerated weight-bearing rehabilitation following MACI for the tibiofemoral joint may be effective, but very little is known on this subject.
主な研究課題は何ですか？
What was the efficacy of an accelerated weight-bearing protocol following matrix-induced autologous chondrocyte implantation of a tibiofemoral joint, 12 months after surgery?
重要な知見は？
- Over the 12 month follow-up period, a significant time effect for all subjective clinical scores that showed improvement was found in each group (p<0.05). A significant group effect for the QOL subscales of the KOOS and a significant interaction effect for the PCS portion of the SF-36 and QOL subscale were also found in each group (p<0.05).
- Post-hoc analysis comparing the two groups indicated significantly better SF-36 PCS scores in the AR group 8 weeks after surgery (p<0.05) and significantly better KOOS QOL scores at 6 and 12 month follow up (p<0.05).
- During the 12 month follow-up, a significant time effect for active knee flexion and extension range of motion, 6 minute walking distance, and 3RM-SLR strength was found (p<0.05). The AR group was able to achieve full knee extension as early as 4 weeks compared to 12 weeks in the CR group.
- A significant group effect was observed for 3RM-SLR strength, which indicated a lower strength discrepancy between operated and non-operated limbs in the AR group when compared to those in the CR group. No between group difference was found regarding 3RM-SLR (p>0.05).
- MRI findings indicated a significant time effect for the MRI composite score, graft infill, signal intensity, border integration, and subchondral lamina during the follow-up period (p<0.05).
- At final follow up (12 months), the degree of defect infill in the AR group was classified as very good (mean 3.57) compared to the CR group which had an average classification of good (mean 3.19).
- 100% of AR patients showed good to excellent infill compared to 85% in the CR group. No reports of graft failure were reported in any group by final follow-up (12 months).
最も覚えておくべきことは？
Patients in both groups experienced significant improvement in all clinical measures during the 12 month follow up. The AR group exhbited significantly better SF-36 PCS scores at 8 weeks and significantly better KOOS quality of life scores at 6 and 12 months postoperatively. No between group differences were found regarding active knee ROM. The AR group achieved full knee extension as early as 4 weeks compared to 12 weeks in the CR group. No difference was found between the groups regarding graft quality, and no side effects occurred due to the implants in either group.
それが私の患者ケアにどのように影響するか？
Results of this study indicated that an accelerated weight-bearing protocol following matrix-induced autologous chrondrocyte implantation of tibiofemoral joints may result in improved physical function and quality of life, along with earlier attainment of full active knee extension than conventional weight bearing regiment. No graft complications or adverse effects occurred due to accelerated weight bearing. Further research with longer follow up periods is required to validate the efficacy of this treatment.
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