2016 AAOS Annual Meeting: Combined Intra-Articular and Intravenous Tranexamic Acid Significantly Reduce Blood Loss in Knee Arthroplasty

60 patients undergoing total knee arthroplasty were randomized to receive either both intravenous (IV) and intra-articular (IA) tranexamic acid administration, or intravenous administration alone. The study was conducted in order to determine whether the addition of IA TXA to IV TXA was associated with a significant reduction in total blood loss. Findings indicated that the combined administration significantly reduced blood loss over both the first and second days after surgery when compared to IV administration alone.