2015 AAOS Annual Meeting: The Effect of Topical Tranexamic Acid during Arthroplasty of the Knee on Blood Loss

131 patients undergoing total knee arthroplasty were randomized to receive tranexamic acid either topically, with 2mg injected intra-articularly following capsular closure, or 1 mg intravenously prior to tourniquet inflation and another 1mg prior to tourniquet deflation. Postoperative hemoglobin levels and cumulative blood loss were assessed for 3 days postoperatively, and length of stay, discharge location, and complication rates were recored. There were no observed significant differences between the two groups in any of the outcomes assessed.