AAHKS 2023: Intrawound Vancomycin For Preventing Peri-Prosthetic Joint Infection .
Efficacy of Intrawound Vancomycin in Prevention of Peri-Prosthetic Joint Infection After Primary TKA
1022 adult patients undergoing primary total knee arthroplasty (TKA) were randomized to receive either intra-wound vancomycin powder (n=507) or no vancomycin powder (n=515). The primary outcome of interest included the peri-prosthetic joint infection (PJI) rate. The secondary outcomes of interest included surgical site infection (SSI) rates, the incidence of revision for PJI/SSI, and the incidence of wound complications. Intra-wound vancomycin powder showed no differences vs. no vancomycin powder in all outcomes except for in the number of minor wound complications which was significantly higher in the Vancomycin group.
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