Hylan G-F 20 Versus Low Molecular Weight Hyaluronic Acids for Knee Osteoarthritis: A Meta-Analysis

Twenty randomized controlled trials (RCTs) were included in a meta-analysis and systematic review comparing pain, treatment-emergent adverse events, and function between Hylan G-F 20 injections and low-molecular-weight hyaluronic acid (LMWHA) injections for knee osteoarthritis. No significant differences between products were observed in pain overall or the incidence of treatment-emergent related adverse events. When subgrouped based on follow-up time, significantly lower pain scores were observed favouring Hylan G-F 20 from 5-12 weeks, though no significant differences were observed at other follow-up time periods.