Less periprosthetic bone loss with ultra-short stem vs conventional stem in THA at 2 years .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2016;4(8):4 Acta Orthop. 2015 Dec;86(6):659-6651 patients with osteoarthritis undergoing total hip arthroplasty were randomized to receive either an uncemented conventional tapered stem or an uncemented ultra-short stem. The purpose of this randomized controlled trial was to compare the different stems in terms of periprosthetic bone loss in the proximal femur, safety, and migration, at 2 years postoperatively. The results suggested that the decrease in periprosthetic bone mineral density (Gruen zone 1 and 1-7) was significantly lower in the ultra-short stem patients. During the first 6 postoperative weeks, the ultra-short stem group displayed greater implant migration, which remained significant at 2 years. Between groups, clinical outcomes were similarly improved at 2 years and adverse events were comparable.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Sim = 1
Incerto = 0,5
Não relevante = 0
Não = 0
A Avaliação dos Critérios de Relato avalia a transparência com que os autores relatam as caraterísticas metodológicas e do ensaio na publicação. A avaliação está dividida em cinco categorias que são apresentadas de seguida.
4/4
Randomization
2/4
Outcome Measurements
4/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
O Índice de Fragilidade é uma ferramenta que auxilia na interpretação de achados significativos, fornecendo uma medida de força para um resultado. O Índice de Fragilidade representa o número de eventos consecutivos que precisam de ser adicionados a um resultado dicotómico para que o resultado deixe de ser significativo. Um número pequeno representa um resultado mais fraco e um número grande representa um resultado mais forte.
Porque é que este estudo era necessário agora?
Total hip arthroplasty (THA) is a common procedure in patients with hip osteoarthritis, and there are various prosthetic designs and techniques utilized to minimize the risk of complications and revisions while maintaining excellent patient outcomes. Periprosthetic bone loss in uncemented femoral stems raises concerns of fracture, and shorter femoral stems have gained popularity as they aim to provide a more physiological load pattern in the femur and reduce stress shielding. The absence of a stem that engages the diaphysis of the femur prevents off-loading of the proximal femur, but may also affect the stability necessary for bone integration of the implant. The present study sought to analyze the effects of an ultra-short uncemented stem in patients with osteoarthritis undergoing THA.
Qual era a principal questão de investigação?
In patients undergoing total hip arthroplasty for the treatment of osteoarthritis, how did an ultra-short uncemented stem compare to a conventional tapered uncemented stem in terms of periprosthetic bone loss in the proximal femur, safety, and achievement of fixation at 2 years postoperatively?
- At 2 years, the decrease in BMD in zone 1 was significantly smaller in the ultra-short stem group compared to the conventional group (MD: 18.2% [95% CI 9.5, 26.8]; p<0.001). In zone 7, the decrease in BMD did not significantly differ between groups (MD: 4.5% [95% CI 2.8, 11.8]; p=0.4).
- At 2 years, the decrease in BMD in the entire periprosthetic region (Zone 1-7), was significantly less in the ultra-short stem group (MD: 5.3% [95% CI 1.5, 9.1]; p=0.02).
- After 6 weeks postoperative, the ultra-short stems demonstrated significantly median maximum total point motion (1.51mm [0.33-5.44]) compared to the conventional stem group (0.74mm [0.13-5.29]), and significance was maintained up to 2 year follow-up (1.71mm [0.39-6.00] vs. 0.87 [0.87-7.47], respectively; p=0.01). Migration had stopped after 3 months for the majority of components in both groups, and all components were stable at 2 years.
- Both groups displayed significant improvements from baseline to 2 years postoperatively in the median HHS and WOMAC scores. However, no significant differences were noted in these outcomes between groups (p=0.2 and p=0.5, respectively)
- The improvement in health-related quality of life (EQ-5D) was similar between groups at 2 years. The number of patients suffering from mid-thigh pain was greater in the conventional group during the first 6 months, without reaching statistical significance at any point.
- Adverse events were similar between groups (Ultra-short: 45 vs. Conventional: 51). Periprosthetic fracture occurred in one patient in the Ultra-short stem group and periprosthetic infection occurred in one patient in the conventional stem group
De que é que me devo lembrar mais?
At 2 years, the decrease in periprosthetic bone mineral density in the proximal femur at Gruen zone 1 was significantly lower in the total hip arthroplasty patients who received an uncemented ultra-short stem when compared to a conventional tapered uncemented stem. During the first 6 postoperative weeks, the ultra-short stem group displayed significantly more migration when compared to conventional stems, this difference lasted to the 2 year follow-up. Between groups, all clinical outcomes (HHS, WOMAC, EQ-5D, mid-thigh pain) were similarly improved at 2 years, and adverse events were comparable.
Como é que isto afectará o tratamento dos meus doentes?
The results of this randomized controlled trial suggest that at 2 years, the use of an uncemented ultra-short stem may reduce periprosthetic bone loss in the greater trochanteric region and along the entire preriprosthetic region, though was associated with greater migration early in the follow-up period compared to a conventional stem. Nevertheless, clinical outcome and adverse events did not appear to be affected within this time frame. Further study is warranted given the small evidence base of high-quality literature on the topic, and limited results regarding long-term stability and survivorship between the two designs.
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