Combination of intravenous and topical application of tranexamic acid in primary total knee arthroplasty: a prospective randomized controlled trial

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

184 patients undergoing unilateral total knee arthroplasty (TKA) were randomized to one of two tranexamic acid groups: an intravenous administration group, or a combined topical and intravenous administration group. Patients in the intravenous group were given 3g of tranexamic acid (TXA) intravenously during surgery. Those in the combined group had a solution composed of 1.5g of TXA and 50mL of normal saline irrigated into the wound after component implantation, and were also given 1.5g of TXA intravenously during surgery. Factors such as blood loss, transfusion rate, swelling ratio, and pain were assessed and compared between groups in the perioperative period up to 4 days. The results demonstrated significant effects of combined administration on maximum hemoglobin drop, postoperative blood loss to drain, pain on postoperative days 2-3, swelling on postoperative days 2-4, and satisfaction upon discharge.