Adhesive capsulitis: Pain & disability improved similarly with 20mg & 40mg corticosteroid .
تم تحديد هذه الدراسة على أنها ذات تأثير كبير محتمل.
يُقدّر مقياس التأثير العالي الذي يعتمد على الذكاء الاصطناعي من OE التأثير المحتمل لورقة بحثية ما من خلال دمج الإشارات من كل من المجلة التي نُشرت فيها والمحتوى العلمي للمقالة نفسها.
تم تطوير نموذج OE High Impact باستخدام أحدث تقنيات معالجة اللغة الطبيعية، ويتنبأ نموذج OE High Impact بدقة أكبر بأداء الاقتباس المستقبلي للدراسة أكثر من معامل تأثير المجلة وحده.
وهذا يتيح التعرف المبكر على الأبحاث ذات المغزى السريري ويساعد القراء على التركيز على المقالات التي من المرجح أن تشكل الممارسة المستقبلية.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(10):33 Am J Sports Med. 2013 May;41(5):1133-9. doi: 10.1177/0363546513480475. Epub 2013 Mar 1863 patients were randomized to determine the effect of varying doses of corticosteroid injections in the treatment of adhesive capsulitis. Participants were allocated to groups of high-dose triamcinolone (40mg), low-dose triamcinolone (20mg), or placebo (control) (1% lidocaine). Results after 12 weeks indicated that pain and disability were more significantly improved with both dosages of corticosteroid compared to control, but there was no difference between 20mg and 40mg triamcinolone. Corticosteroid injections also had a beneficial effect on passive range of motion in flexion, abduction, and internal rotation
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
نعم = 1
غير مؤكد = 0.5
غير ذي صلة = 0
لا = 0
يقيّم تقييم معايير الإبلاغ الشفافية التي يبلغ بها المؤلفون عن الخصائص المنهجية والتجريبية للتجربة في المنشور. ينقسم التقييم إلى خمس فئات معروضة أدناه.
4/4
Randomization
3/4
Outcome Measurements
4/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
مؤشر الهشاشة هو أداة تساعد في تفسير النتائج المهمة، وتوفر مقياسًا لقوة النتيجة. ويمثل مؤشر الهشاشة عدد الأحداث المتتالية التي يجب إضافتها إلى نتيجة ثنائية التفرع لجعل النتيجة غير مهمة. يمثل الرقم الصغير نتيجة أضعف ويمثل الرقم الكبير نتيجة أقوى.
لماذا كانت هناك حاجة لهذه الدراسة الآن؟
Although intra-articular injections of corticosteroid have been and remain a mainstay in the treatment of adhesive capsulitis, there is little evidence available to guide clinician decision-making with respect to dosage. It has been suggested that the efficacy of steroid injections conforms to a dose-dependent relationship, with increasing dose leading to a more favourable outcome. Yet, simultaneously, the severity of cartilage damage linked to corticosteroid injection is also thought to be manifested through the same dose dependency. Therefore, it has become crucial to determine the optimal steroid dosage to use in the treatment of adhesive capsulitis.
ما هو سؤال البحث الرئيسي؟
What was the comparative efficacy of 20mg triamcinolone acetonide, 40mg triamcinonlone acetonide, and placebo in adhesive capsulitis treatment?
- SPADI scores were reduced from 37.9 (SD 14.2) at baseline to 14.1 (SD 12.4) at 12 weeks in the high-dose group, 37.6 (SD 13.7) to 18.3 (SD 14.0) in the low-dose group, and 44.2 (SD 12.2) to 37.1 (SD 10.4) in the placebo group. Improvements in both the high-dose and low-dose steroid groups were significant compared to placebo (P<0.001 and P=0.001, respectively), although the difference between steroid groups was not significant (P=0.826).
- Marked reductions in VAS pain were observed for the steroid groups; the high-dose group from 5.2 (SD 1.7) at baseline to 2.4 (SD 1.7) at 12 weeks, and the low-dose group from 4.9 (SD 1.3) to 2.4 (SD 1.3). The difference between these two group was not significant (P=0.999). Compared to placebo (reduction from 5.5 to 4.6), both steroid groups were observed to have a significantly greater reduction (High-dose: P<0.001; Low-dose: P=0.001).
- Flexion, abduction, and internal rotation were significantly better in the high- and low-dose groups compared to placebo group (all P<0.005). The difference between the steroid groups was not significant for these measurements, however (P=0.485, 0.092, and 0.495, respectively).
- The group-by-time interactions for extension and external rotation were not significant (P=0.331 and 0.094, respectively), however the group-by-time interactions for SPADI (P=0.007), VAS (P=0.004), flexion (P=0.024), abduction (P<0.001) and internal rotation (P=0.027) were all significant.
- Facial flushing was observed in 3 high-dose participants and 1 low-dose participant. Dizziness due to a vasovagal reaction occurred in 1 patient of the placebo group and 1 in the low-dose group. These were the only complications reported.
ما الذي يجب أن أتذكره أكثر؟
Injection of either 20mg or 40mg triamcinolone acetonide led to significantly reduced pain and disability compared to a control injection in the treatment of adhesive capsulitis. Furthermore, improved range of motion was observed with the corticosteroid injections. There were no differences in outcomes based on dose of triamcinolone acetonide received, and neither dose was associated with any serious adverse event.
كيف سيؤثر ذلك على رعاية مرضاي؟
At 12 weeks post injection there appears to be no difference between a lower (20mg) and a higher dose (40mg) of triamcinolone. Given the lack of difference, a lower dose may be considered to avoid any potential complications that may exist with higher doses (even though the study found none). However, further investigation with a larger cohort of patients is required to confirm the efficacies of both high- and low-dose corticosteroid injections. Long-term effect of single injections should also be determined in future studies.
تنويه
هذا المحتوى الموجود في هذه الصفحة هو لأغراض إعلامية فقط وليس الغرض منه أن يكون بديلاً عن المشورة الطبية المتخصصة أو التشخيص أو العلاج. إذا كنت بحاجة إلى علاج طبي، اطلب دائمًا مشورة طبيبك أو اذهب إلى أقرب قسم طوارئ إليك. الآراء والمعتقدات ووجهات النظر التي يعبر عنها الأفراد في المحتوى الموجود في هذه الصفحة لا تعكس آراء ومعتقدات ووجهات نظر أورثوإيفيدنس.
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