Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(15):11 J Shoulder Elbow Surg. 2021 Jun;30(6): 1316-1323.¿Qué significa esto para mi consulta?
Results of this study suggest that utilizing 5% benzoyl peroxide gel on the shoulder area before a patient undergoes a primary, elective open shoulder surgery can significantly reduce the amount of bacterial growth pre-operatively and the total bacterial load both before and after surgery. However, this study was limited by the small sample size of 106 patients and lack of blinding which can increase bias in the results. Thus, future randomized controlled trials incorporating a larger sample size and blinding of outcome assessors are needed to confirm the findings of this trial
Resumen del estudio
One hundred and six patients scheduled for a primary, elective open shoulder surgery were randomized to prepare the shoulder before surgery by using 5% benzoyl peroxide topical solution (n=50) or soap to shower according to local guidelines (n=56). Outcomes of interest included the following: bacterial colonization in the skin and dermis, and the incidence of deep surgical site infection (SSI). All outcomes were measured pre-operatively at the following timepoints: in the pre-operative area (T1), immediately before skin incision (T2), after skin incision in a sterile field (T3), and immediately after skin incision (T4). Results revealed a significantly lower number of patients with detectable Cutibacterium acnes (C acnes) using skin swabs in the benzoyl peroxide group vs control at T1 and T2 (p<0.05). As well, the total viable count of C acnes was significantly lower in the benzoyl peroxide group vs control at all timepoints (p<0.05 for all). With respect to dermal skin swabs, no significant difference was observed between the two groups which was measured immediately after skin incision (p=0.25).
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