5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man--a PET study with [11C]raclopride
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):15 Neuropsychopharmacology. 1999 23-Feb;():. 10.1016/S0893-133X(98)00108-0What this means for my practice?
Psilocybin produced changes in mood, disturbances in thinking, illusions, elementary and complex visual hallucinations and impairment of ego-functioning in the subjects. Most prominently, subjects experienced derealisation and depersonalisation associated with heightened mood or euphoria. Psilocybin also decreased raclopride binding in the caudate nucleus and putamen, reflecting an increase in striatal dopamine. The fact that depersonalisation subscores and the change in D2 receptor BP were correlated suggest that some of the psychosis-like symptoms were due to increased striatal dopamine activity. While more detailed follow-up studies are necessary given the small sample size, stimulation of 5-HT serotonin receptors may lead to increase in striatal dopamine concentration, contributing to the psychotomimetic effects of psilocybin.
Study Summary
Seven healthy subjects underwent a single-blind, randomized, placebo-controlled PET scan study to examine the effect of psilocybin on the binding of a radioligand ([11C]raclopride) to D2 dopamine receptors in the striatum. Subjects randomly received placebo or psilocybin and PET scans were performed at monthly intervals. Psilocybin significantly decreased raclopride receptor binding potential (BP) bilaterally in the caudate nucleus and putamen, consistent with an increase in endogenous dopamine. Changes in raclopride BP in the ventral striatum correlated with depersonalization associated with euphoria.
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