Preoperative dose of etoricoxib reduces postoperative morphine consumption .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(6):18 Acta Orthop. 2012 Dec;83(6):642-7. doi: 10.3109/17453674.2012.747053. Epub 2012 Nov 9A total of 66 patients undergoing elective therapeutic knee arthroscopy were included in this trial to examine the effects of etoricoxib on post operative analgesia and opioid consumption. Patients received either 120 mg of etoricoxib or a placebo. Over the first 24 hours, the total postoperative morphine consumption was higher in the placebo group (24 mg) than the etoricoxib group (9 mg). The etoricoxib group also demonstrated reduced pain intensity levels at rest and patient satisfaction with the analgesia provided was greater during the first postoperative day.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
نعم = 1
غير مؤكد = 0.5
غير ذي صلة = 0
لا = 0
يقيّم تقييم معايير الإبلاغ الشفافية التي يبلغ بها المؤلفون عن الخصائص المنهجية والتجريبية للتجربة في المنشور. ينقسم التقييم إلى خمس فئات معروضة أدناه.
4/4
Randomization
3/4
Outcome Measurements
2/4
Inclusion / Exclusion
4/4
Therapy Description
3/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
مؤشر الهشاشة هو أداة تساعد في تفسير النتائج المهمة، وتوفر مقياسًا لقوة النتيجة. ويمثل مؤشر الهشاشة عدد الأحداث المتتالية التي يجب إضافتها إلى نتيجة ثنائية التفرع لجعل النتيجة غير مهمة. يمثل الرقم الصغير نتيجة أضعف ويمثل الرقم الكبير نتيجة أقوى.
لماذا كانت هناك حاجة لهذه الدراسة الآن؟
In order to reduce postoperative morphine consumption, various studies have been conducted on the postoperative or intraoperative use of coxibs. Etoricoxib has the longest duration of analgesic action (lasting 22-24 hours) out of the currently registered COX-2 inhibitors. Several studies have confirmed its capacity to provide pain relief after various types of abdominal and trauma surgeries. However, no data exists on the efficacy of the preoperative administration of a single dose of etoricoxib for the attenuation of postoperative pain after therapeutic knee arthroscopy (performed under general anesthesia). Hence, this study is aimed to determine whether a single preoperative dose of 120 mg etoricoxib before knee arthroscopy would reduce patients’ postoperative opioid consumption.
ما هو سؤال البحث الرئيسي؟
Does a single preoperative dose of 120 mg etoricoxib reduce the need for additional opioids after therapeutic arthroscopic knee surgery, measured over 24 hours?
- During the 24 hours, patients who received etoricoxib required 14.7 mg (95% CI: 10.2-19.2) less morphine than the patients who received the placebo (p < 0.001, ANOVA).
- Etoricoxib group demonstrated lower overall pain at rest than the placebo group (p = 0.01, ANOVA), but there was no statistically significant difference for overall pain on movement (p = 0.07).
- Patients who received etoricoxib experienced significantly less pain at rest and on movement at 0, 4, 6, and 24 h.
- The etoricoxib group produced significantly higher patient satisfaction at each time point than the control group (p < 0.001 at 24h).
- The difference in the number of patients suffering adverse events was not statistically significant between the two groups (p = 0.3, Fisher's exact test).
ما الذي يجب أن أتذكره أكثر؟
Patients given 120 mg of etoricoxib before therapeutic arthroscopy had about a 60 percent reduction in morphine consumption and felt less pain during the first 24 postoperative hours. Despite the fact that patients could dose their morphine in accordance to their needs, etoricoxib provided exceptional analgesia; hence, while the placebo group used more than twice the amount of morphine than the intervention group, they had far inferior analgesia and were less satisfied with their analgesic therapy
كيف سيؤثر ذلك على رعاية مرضاي؟
Premedication with etoricoxib appears to provide a number of possible advantages for patients undergoing knee arthroscopy which include; a reduction in opioid consumption, postoperative pain and an improvement in patient satisfaction. However, the sample size of this study was small and larger trials are required to confirm its findings.
تنويه
هذا المحتوى الموجود في هذه الصفحة هو لأغراض إعلامية فقط وليس الغرض منه أن يكون بديلاً عن المشورة الطبية المتخصصة أو التشخيص أو العلاج. إذا كنت بحاجة إلى علاج طبي، اطلب دائمًا مشورة طبيبك أو اذهب إلى أقرب قسم طوارئ إليك. الآراء والمعتقدات ووجهات النظر التي يعبر عنها الأفراد في المحتوى الموجود في هذه الصفحة لا تعكس آراء ومعتقدات ووجهات نظر أورثوإيفيدنس.
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