Intra-Articular Platelet-Rich Plasma Injection After Anterior Cruciate Ligament Reconstruction: A Randomized Clinical Trial.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2024;12(21):8 JAMA Netw Open . 2024 May 1;7(5):e2410134. doi: 10.1001/jamanetworkopen.2024.10134.What this means for my practice?
Clinicians should remember that postoperative PRP injections do not improve knee function or symptoms at 12 months post-ACLR, indicating limited utility for routine clinical practice in this context. Although there were temporary improvements in sports-related outcomes and graft maturity at 6 months, these did not translate to sustained functional benefits. Limitations include the unblinded design for participants, potentially influencing subjective outcomes, and a relatively short follow-up time for complete graft maturation assessment.
Study Summary
One hundred twenty patients with anterior cruciate ligament (ACL) injuries were randomized to receive either postoperative intra-articular PRP injection (n=60) or no injection (control group; n=60) following ACL reconstruction. The primary outcome was the mean Knee Injury and Osteoarthritis Outcome Score (KOOS4) at 12 months postoperatively. Secondary outcomes included patient-reported outcomes, graft maturity (via MRI), and physical examinations conducted at 3, 6, and 12 months. Overall, the results indicated no statistically significant improvement in knee function or symptoms in the PRP group at 12 months. At 6 months, the PRP group showed a temporary improvement in the KOOS sports and recreation score and graft maturity.
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