Costal Chondrocyte-Derived Pellet-Type Autologous Chondrocyte Implantation Versus Microfracture for the Treatment of Articular Cartilage Defects: A 5-Year Follow-up of a Prospective Randomized Trial.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2024;12(21):7 Am J Sports Med . 2024 Feb;52(2):362-367. doi: 10.1177/03635465231222797.What this means for my practice?
CCP-ACI shows promise as a superior treatment to MFx for long-term cartilage repair, as it achieved better clinical and structural outcomes at 5 years, suggesting it may provide more sustained functional improvement. Limitations include the small sample size and variations in lesion size between groups and patient activity levels, which may affect generalizability.
Study Summary
Twenty-five patients with knee articular cartilage defects were randomized to receive either CCP-ACI (n=16) or MFx (n=9). The primary outcome was the MOCART score, assessing cartilage repair via MRI. Secondary outcomes included the Lysholm score, International Knee Documentation Committee (IKDC) score, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) for pain. Outcomes were evaluated up to 5 years post-procedure. Overall, the study found CCP-ACI to be significantly more effective in improving structural repair and clinical outcomes, as evidenced by superior MOCART, Lysholm, and KOOS scores at 5 years compared to MFx. These results suggest that CCP-ACI may offer a more durable cartilage repair method than MFx for patients with knee cartilage defects.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
