100 patients with knee osteoarthritis not eligible for total knee replacement were randomly assigned to either a 12-week non-surgical program (MEDIC treatment), consisting of neuromuscular exercise, educational sessions, insoles, diet changes, and pain medication, or to usual care with educational pamphlets. The purpose of this study was to determine the effects of a multi-modal non-surgical treatment on patient pain, function, and quality of life. Patients enrolled in the MEDIC treatment demonstrated significantly greater improvement in the average score for the KOOS subscales of pain, symptoms, ADL and QoL, 4 out of 5 KOOS subscores (pain, symptoms, ADL, and QoL), a 20-m walk test, and the EQ-5D index compared to patients who received usual care. However, there was no differences between groups in KOOS subscale scores for sports/rec, the Timed Up and Go test, the EQ-5D VAS subscale, body weight, or analgesic intake.