Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

Topical TXA reduces blood loss compared to IV TXA in bilateral total knee arthroplasty

J Arthroplasty. 2016 Jul;31(7):1442-8

IV and topical TXA superior to placebo for hematological outcomes after PLIF

World Neurosurg. 2019 Feb;122:e821-e827.

ISAKOS2017: Assessment of topical TXA efficacy in reverse total shoulder arthroplasty

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

Combined Topical & IV TXA superior to topical TXA alone for reducing blood loss in TKA

J Arthroplasty. 2015 May;30(5):776-80

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

Large-scale trial comparing topical and intravenous TXA efficacy in total knee arthroplasty

J Bone Joint Surg Am. 2018 Jun 20;100(12):1023-1029

Topical TXA and IV TXA similarly effective in reducing blood loss in tourniquetless TKA

J Arthroplasty. 2016 Nov;31(11):2465-2470

Addition of diluted epinephrine to topical TXA for reducing blood loss in THA

J Arthroplasty. 2015 Dec;30(12):2196-200

Combined IV & topical TXA reduces blood loss and transfusion rate in THA

J Bone Joint Surg Am. 2016 Jun 15;98(12):983-91

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

Topical TXA superior to placebo in reducing blood loss after instrumented posterior spinal fusion

Asian Spine J. 2019 Feb;13(1):146-154.

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

Combined IV-topical TXA more effective than IV TXA alone in total hip and knee arthroplasty

Int J Surg. 2016 Dec;36(Pt A):324-329

AAOS: Blood loss and transfusion rates do not differ between tranexamic acid preperations

ISAKOS2017: Comparison of safety and efficacy between topical and IV tranexamic acid in TKA

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25