TKA: Topical Fibrin Spray and Tranexamic acid reduce blood loss

J Bone Joint Surg Br. 2007 Mar;89(3):306-9

TKA: Topical fibrin spray significantly reduces total blood loss

Knee. 2012 Aug;19(4):295-8. Epub 2011 Jul 5

Tranexamic acid and fibrin spray equally effective in reducing blood loss following THA

Acta Orthop. 2011 Dec;82(6):660-3. Epub 2011 Oct 17

Fibrin spray reduces blood loss vs standard electrocautery in THR

Int Orthop. 2013 Jul;37(7):1213-7. doi: 10.1007/s00264-013-1903-8. Epub 2013 May 18

Tranexamic acid reduces blood loss significantly more than fibrin glue following TKA

J Bone Joint Surg Am. 2013 Nov 20;95(22):2001-7

Efficacy of fibrin sealant in total hip and total knee arthroplasty

Int J Surg. 2016 Dec;36(Pt A):127-137

TKA: No effect of fibrin sealant on reducing blood loss and functional recovery

Acta Orthop. 2013 Apr;84(2):153-8. doi: 10.3109/17453674.2013.769082. Epub 2013 Jan 25

No significant effect of fibrin sealant on postoperative function following total knee arthroplasty

PLoS One. 2018 Jul 25;13(7):e0200804. doi: 10.1371/journal.pone.0200804

No significant effect of topical FS or TXA on blood loss in cases of sub-capital femoral fracture

Arch Orthop Trauma Surg. 2019 May;139(5):597-604. doi: 10.1007/s00402-018-3089-4

Evicel fibrin sealant does not appear to reduce total blood loss/transfusion rates for TKA

J Arthroplasty. 2014 Aug;29(8):1516-20

No effect of topical fibrinogen spray on blood loss and transfusion in TKA

Clin Orthop Relat Res. 2014 Jan;472(1):272-6. doi: 10.1007/s11999-013-3036-1

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

Outcome of different doses of fibrin sealant similar in TKA

Blood Coagul Fibrinolysis. 2012 Jun;23(4):278-84. doi: 10.1097/MBC.0b013e3283518846

Fibrin sealant can reduce bloody drainage and hemoglobin loss post-total knee arthroplasty

J Bone Joint Surg Am. 2001 Oct;83-A(10):1503-5

Efficacy of fibrin sealant on blood loss in total knee arthroplasty

Orthop Traumatol Surg Res. 2015 May;101(3):331-9

Assessing the efficacy of topical diclofenac in the treatment of knee osteoarthritis pain

J Rheumatol. 2006 Mar;33(3):567-73

Topical NSAIDs demonstrate significant reduction in pain versus placebo for treatment of knee OA

J Rheumatol. 2006 Sep;33(9):1841-4

Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

Topical NSAIDs equally effective as oral NSAIDs for knee pain, with fewer adverse effects

BMJ. 2008 Jan 19;336(7636):138-42. Epub 2007 Dec 4.

AAOS: Topical tranexamic acid effacacious method for blood loss management in TKA