IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

Combination of intravenous and topical TXA improves outcomes following primary TKA

J Arthroplasty. 2014 Dec;29(12):2342-6.

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion

BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9

AAOS 2015: No difference between intra-articular & intravenous TXA administration in TKA

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

Large-scale trial comparing topical and intravenous TXA efficacy in total knee arthroplasty

J Bone Joint Surg Am. 2018 Jun 20;100(12):1023-1029

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

AAOS2018: IV-TXA reduces blood loss, not transfusion rate, in reverse total shoulder arthroplasty

Preop oral TXA demonstrates noninferiority to IV TXA in TKA for hemostasis

J Arthroplasty. 2016 Sep;31(9 Suppl):26-30

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

Intravenous and topical tranexamic acid have similar efficacy in TKA

Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.

Combined IV & topical TXA reduces blood loss and transfusion rate in THA

J Bone Joint Surg Am. 2016 Jun 15;98(12):983-91