IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

Combination of intravenous and topical TXA improves outcomes following primary TKA

J Arthroplasty. 2014 Dec;29(12):2342-6.

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion

BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

AAOS 2015: No difference between intra-articular & intravenous TXA administration in TKA

Combined IV-topical TXA more effective than IV TXA alone in total hip and knee arthroplasty

Int J Surg. 2016 Dec;36(Pt A):324-329

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

Topical TXA reduces blood loss compared to IV TXA in bilateral total knee arthroplasty

J Arthroplasty. 2016 Jul;31(7):1442-8

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

Large-scale trial comparing topical and intravenous TXA efficacy in total knee arthroplasty

J Bone Joint Surg Am. 2018 Jun 20;100(12):1023-1029

Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.