Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Combination of intravenous and topical TXA improves outcomes following primary TKA

J Arthroplasty. 2014 Dec;29(12):2342-6.

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

AAOS 2015: No difference between intra-articular & intravenous TXA administration in TKA

Large-scale trial comparing topical and intravenous TXA efficacy in total knee arthroplasty

J Bone Joint Surg Am. 2018 Jun 20;100(12):1023-1029

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

COA/ICORS2019: Blood loss, Hb drop, and transfusion rate similar between IA TXA and IV TXA in TKA

Equivalent blood conservation with intra-articular and intravenous TXA in TKA

J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44

Intravenous, intraarticular irrigation, and drain administration of TXA in TKA

J Arthroplasty. 2014 Aug;29(8):1521-4

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

Combined IV-topical TXA more effective than IV TXA alone in total hip and knee arthroplasty

Int J Surg. 2016 Dec;36(Pt A):324-329

Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion

BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA