Similar effect of intra-articular vs IV TXA on Hb drop, LoS, and transfusion following TKA

J Arthroplasty. 2017 Jan;32(1):28-32

TKA: Intra-articular tranexamic acid reduces blood loss and transfusion requirements

Knee Surg Sports Traumatol Arthrosc. 2012 Dec;20(12):2494-501. doi: 10.1007/s00167-012-1942-5. Epub 2012 Mar 15

AAOS 2015: Tranexamic acid effectively lowers blood loss following TKA without tourniquet

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective

J Arthroplasty. 2017 Jan;32(1):37-42

Assessment of IV, IA, and oral tranaexamic acid safety in total joint arthroplasty

J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023

AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty

ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

IV tranexamic acid reduces postoperative autologous blood retransfusion in THA and TKA

Transfusion. 2014 Jan;54(1):31-41. doi: 10.1111/trf.12224.

TXA effective in reducing blood loss in mini-invasive TKA with postoperative rivaroxaban

J Arthroplasty. 2017 Mar;32(3):801-806

Intraarticular TXA appears safe and effective in primary total hip arthroplasty

Int J Surg. 2015 Mar;15:134-9

Tranexamic acid reduces blood transfusion requirements during surgery

BMJ. 2012 May 17;344:e3054. doi: 10.1136/bmj.e3054

COA2017: IA TXA reduces blood loss, not transfusion rate, in THA and TKA

Effect of tranexamic acid and indirect factor Xa inhibitor on blood loss and DVT after TKA

Knee Surg Sports Traumatol Arthrosc. 2013 Nov;21(11):2611-7

TXA is effective and safe for reducing blood loss and transfusion in TKA patients

Eur J Orthop Surg Traumatol. 2015 Apr;25(3):525-41

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA

Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22

AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

Similar reduction in total blood loss with intravenous/articular TXA administration in TKA

Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.

Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27. doi: 10.1007/s00402-013-1761-2. Epub 2013 Apr 25

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA