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Talar Osteochondral lesions: Adjunct hyaluronan injection improves microfracture outcomes

Knee Surg Sports Traumatol Arthrosc. 2012 Jul;20(7):1398-403. doi: 10.1007/s00167-011-1856-7. Epub 2011 Dec 29

RCT Foot & Ankle Lesion Lower Extremity Ankle Bone Talus Hyaluronan Injection Hyaluronic Microfracture - Hide

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Hyaluronan injection beneficial for OA patients over age 65 with poor baseline function

Ann Rheum Dis. 1996 Jul;55(7):424-31.

RCT Osteoarthritis Lower Extremity Knee Arthritis Hyaluronan Injections Phosphate Placebo Saline - Hide

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Arthroscopic evaluation at one year post-hyaluronan injection in knee OA

Osteoarthritis Cartilage. 1997 May;5(3):153-60

RCT Osteoarthritis Lower Extremity Knee Arthritis Hyalgan Hyaluronan Arthroscopic Arthroscopy Injection Control - Hide

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OARSI 2016: Allogenic mesenchymal precursor cells + hyaluronan injection after ACL repair

RCT Trauma Joint Ligament Hyaluronan Allogeneic Anterior Cruciate HA Reconstruction Single Injection - Hide

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OARSI 2016: Efficacy & safety of Hyaluronan with/without Botox for patellar tendinopathy

RCT General Orthopaedics Athletes Lower Extremity Knee Bone Patella Tendinopathy Hyaluronan Saline Placebo Toxin - Hide

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IA-hyaluronan injections and time-to-knee replacement in those with K-L grade IV knee OA

The Open Arthritis Journal, 2008, 1, 1-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Inflammation Adant Hyaluronan Injections HA IV Replacement Surgery Saline - Hide

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Comparison of two hyaluronan preperations to placebo for injection treatment of knee OA

Rheumatology (Oxford). 2002 Nov;41(11):1240-8.

RCT Osteoarthritis Lower Extremity Knee Arthritis Astra Lakemedel Artzal Hyaluronan Injections Placebo - Hide

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Hyaluronon injection shows no benefit over placebo for treatment of knee osteoarthritis

Ann Rheum Dis. 1994 Aug;53(8):529-34

RCT Osteoarthritis Lower Extremity Knee Arthritis Hyalgan Hyaluronan Injections Placebo Saline Solution - Hide

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Reduced pain and disability over 26 weeks in patients treated with IA hyaluronan vs. sham

Clin Ther. 1998 May-Jun;20(3):410-23

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Biomatrix Hylan Hyaluronan Injections HA Saline - Hide

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Autologous conditioned serum effective in knee osteoarthritis vs. hyaluronan or saline

Osteoarthritis Cartilage. 2009 Feb;17(2):152-60

RCT Osteoarthritis Lower Extremity Knee Arthritis Ormed Hyaluronan Autologous Conditioned Serum Injections Saline - Hide

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Efficacy and safety of five weekly HA vs placebo injections in the treatment of knee OA

J Rheumatol. 2004 Apr;31(4):775-82.

RCT Osteoarthritis Lower Extremity Knee Arthritis Seikagaku Artz Hyaluronan HA Phosphate Placebo Injections - Hide

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Knee OA: Significant decrease in proprioception error after three HA vs saline injections

J Back Musculoskelet Rehabil. 2009;22(1):1-9.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Biodex Wyeth Hylan Hyaluronan Injections HA Placebo Proprioception Saline - Hide

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Short-term pain and function benefit with HA for knee OA in trials with low risk of bias

RMD Open. 2015 May 14;1(1):e000071

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Pain Hyaluronan Hyaluronic Acid Injections IA Placebo IAHA Medical Viscosupplementation - Hide

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Efficacy of hyaluronic acid for pain reduction in knee OA versus control arthrocentesis

J Rheumatol. 2005 Oct;32(10):1928-36

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Anika Hyaluronan Injections Control Arthrocentesis High-Molecular-Weight HMW HA Hyaluronic Acid Reduction - Hide

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ISAKOS 2015: Similar effects of hyaluronic acid w/ varying average molecular weight in OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Seikagaku Artz Hyaluronan HA Hyaluronic Acid Molecular Weight - Hide

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Protocol of muscle strengthening, ultrasound & IA hyaluronan effective for knee OA

Arthritis Rheum. 2005 Dec 15;53(6):812-20

RCT Osteoarthritis Lower Extremity Knee Arthritis Hyalgan Hyaluronan Isokinetic Muscle Strengthening Ultrasound - Hide

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Triamcinolone and Hyaluronan both effective in patients with OA of the knee

Knee. 2009 Dec;16(6):466-72. Epub 2009 Apr 10.

RCT Osteoarthritis Lower Extremity Knee Arthritis Hyaluronan Triamcinolone Intraarticular Injections - Hide

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The use of intra-articular hyaluronic acid in the treatment of Kashin-Beck disease

Osteoarthritis Cartilage. 2014 Jun;22(6):718-25

Meta-analysis Metabolic Disorders Lower Extremity Knee Hyaluronan Injection Control Hyaluronate Hyaluronic Acid IAHA Vitamin - Hide

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Hyaluronic acid improves pain in patients with hip osteoarthritis at 3-month evaluation

J Arthroplasty. 2015 Mar;30(3):507-511.

Meta-analysis Osteoarthritis Lower Extremity Hip Arthritis Pain Hylan Hyaluronan Conservative Hyaluronic Acid Placebo Medication Sodium Hyaluronate Viscosupplementation - Hide

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Intra-articular hyaluronic acid provides longer pain relief as compared to corticosteroid

Exp Ther Med. 2015 Feb;9(2):493-500.

Meta-analysis General Orthopaedics Osteoarthritis Lower Extremity Knee Arthritis Pain Hyaluronan Corticosteroid Flexion HA Hyaluronic Acid Injection Injections Of Hyaluronic Acid - Hide

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Talar Osteochondral lesions: Adjunct hyaluronan injection improves microfracture outcomes

Hyaluronan injection beneficial for OA patients over age 65 with poor baseline function

Arthroscopic evaluation at one year post-hyaluronan injection in knee OA

OARSI 2016: Allogenic mesenchymal precursor cells + hyaluronan injection after ACL repair

OARSI 2016: Efficacy & safety of Hyaluronan with/without Botox for patellar tendinopathy

IA-hyaluronan injections and time-to-knee replacement in those with K-L grade IV knee OA

Comparison of two hyaluronan preperations to placebo for injection treatment of knee OA

Hyaluronon injection shows no benefit over placebo for treatment of knee osteoarthritis

Reduced pain and disability over 26 weeks in patients treated with IA hyaluronan vs. sham

Autologous conditioned serum effective in knee osteoarthritis vs. hyaluronan or saline

Efficacy and safety of five weekly HA vs placebo injections in the treatment of knee OA

Knee OA: Significant decrease in proprioception error after three HA vs saline injections

Short-term pain and function benefit with HA for knee OA in trials with low risk of bias

Efficacy of hyaluronic acid for pain reduction in knee OA versus control arthrocentesis

ISAKOS 2015: Similar effects of hyaluronic acid w/ varying average molecular weight in OA

Protocol of muscle strengthening, ultrasound & IA hyaluronan effective for knee OA

Triamcinolone and Hyaluronan both effective in patients with OA of the knee

The use of intra-articular hyaluronic acid in the treatment of Kashin-Beck disease

Hyaluronic acid improves pain in patients with hip osteoarthritis at 3-month evaluation

Intra-articular hyaluronic acid provides longer pain relief as compared to corticosteroid

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