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Evidence Series
Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA
Knee. 2015 Mar;22(2):131-5
Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty
J Arthroplasty. 2018 Mar;33(3):786-793
Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty
J Bone Joint Surg Am. 2016 May 18;98(10):835-41
IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective
J Arthroplasty. 2017 Jan;32(1):37-42
Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA
BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340
Intravenous and topical tranexamic acid have similar efficacy in TKA
Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.
Similar effect of intra-articular vs IV TXA on Hb drop, LoS, and transfusion following TKA
J Arthroplasty. 2017 Jan;32(1):28-32
IV and topical tranexamic acid protocols reduce blood loss and transfusion needs in THA
J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023
Similar reduction in total blood loss with intravenous/articular TXA administration in TKA
Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.
Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion
BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9
TXA is effective and safe for reducing blood loss and transfusion in TKA patients
Eur J Orthop Surg Traumatol. 2015 Apr;25(3):525-41
Similar efficacy of oral TXA to IA TXA in total knee arthroplasty without a tourniquet
BMC Musculoskelet Disord. 2018 Mar 15;19(1):85
Topical TXA reduces transfusion and blood loss in THA compared to placebo
J Arthroplasty. 2014 Dec;29(12):2452-6
Intravenous, intraarticular irrigation, and drain administration of TXA in TKA
J Arthroplasty. 2014 Aug;29(8):1521-4