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Arthroplasty
Similar efficacy of oral TXA to IA TXA in total knee arthroplasty without a tourniquet
BMC Musculoskelet Disord. 2018 Mar 15;19(1):85
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General Orthopaedics
No Significant Differences in Blood Loss or Clinical Outcomes with IA-TXA in ACL Reconstruction
Orthop J Sports Med. 2020 22-Jul;():. 10.1177/2325967120933135
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Arthroplasty
COA/ICORS2019: Blood loss, Hb drop, and transfusion rate similar between IA TXA and IV TXA in TKA
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Arthroplasty
Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion
BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9
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Arthroplasty
IA-TXA effective compared to placebo for blood loss and transfusion reduction in TKA
J Knee Surg. 2018 Jan;31(1):56-67
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Arthroplasty
Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty
J Arthroplasty. 2018 Mar;33(3):786-793
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Arthroplasty
IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective
J Arthroplasty. 2017 Jan;32(1):37-42
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Sports Medicine
ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction
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Arthroplasty
COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty
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Arthroplasty
COA2017: IA TXA reduces blood loss, not transfusion rate, in THA and TKA
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Arthroplasty
AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty
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Arthroplasty
High Impact
This study has been identified as potentially high impact. OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself. Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone. This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty
J Bone Joint Surg Am. 2016 May 18;98(10):835-41
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Arthroplasty
AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA
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Arthroplasty
Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA
Knee. 2015 Mar;22(2):131-5
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