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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Bupivacaine Analgesia Analgesic Arthroscopic Surgery Arthroscopy IA Placebo Reduction Single-Dose - Hide

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Higher OMERACT-OARSI response rate following IA-HA injection vs steroid or placebo

Br J Sports Med. 2016 Jan;50(2):84-92

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Corticosteroid HA Injection IA-HA Injections Of Hyaluronic Acid Low-Molecular-Weight Placebo Saline Steroid Viscosupplementation - Hide

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Single-Dose IA ropivacaine reduces pain up to 8 hours post arthroscopic knee surgery

Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1651-9

Meta-analysis Arthroplasty Lower Extremity Knee Pain Analgesic Anterior Cruciate Arthroscopic Arthroscopy IA Ropivacaine Placebo Post-Operative Post-Surgery Single-Dose - Hide

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Comparison for IA corticosteroid versus saline injection following lavage for knee OA

Rheumatology (Oxford). 2003 Dec;42(12):1477-85

RCT Osteoarthritis Lower Extremity Knee Arthritis Arthroscopy Injection IA Corticosteroid Lavage Methylprednisolone Acetate Placebo Saline - Hide

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IA ketorolac has no significant analgesic effect relative to placebo for post-knee arthroscopy pain

Acta Anaesthesiol Scand. 2018 Jul;62(6):829-838

RCT Sports Medicine Lower Extremity Knee Inflammation Pain Arthroscopy IA Ketorolac Placebo - Hide

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Addition of IA steroid injection to exercise not efficacious for knee OA inflammation

Osteoarthritis Cartilage. 2016 May;24(5):814-21

RCT Osteoarthritis Lower Extremity Knee Joint Tibiofemoral Arthritis Inflammation Pfizer Methylprednisolone Lidocaine Steroid Injection Corticosteroid Depomedrol Exercise IA Injection Isotonic Saline Physical Therapy Placebo Ultrasound - Hide

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Safety and efficacy of IA bupivacaine for pain management after total joint arthroplasty

BMJ Open. 2016 Jul 12;6(7):e011325

Meta-analysis Arthroplasty TJA Pain IA Bupivacaine Intraarticular Bupivacaine Narcotic Placebo Replacement - Hide

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Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

RCT Arthroplasty Lower Extremity Knee Pharmacia Tranexamic Acid Bilateral IA TXA IV Placebo Saline - Hide

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Efficacy of joint lavage and/or IA CS injection in knee OA treatment; 2x2 factorial trial

Arthritis Rheum. 1999 Mar;42(3):475-82

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Injection IA Placebo Lavage - Hide

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IA bupivacaine and morphine reduces pain in arthroscopic knee surgery compared to placebo

BMJ Open. 2015 Jun 15;5(6):e006815

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Pain Morphine Analgesia Arthroscopic Surgery Arthroscopy IA Bupivacaine Placebo Saline Single-Dose - Hide

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Similar changes in clinical & radiographic results after 2 years with IA steroid vs saline

Arthritis Rheum. 2003 Feb;48(2):370-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Injections IA Corticosteroid IA Saline Steroid Triamcinolone Acetonide - Hide

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IA-TXA effective compared to placebo for blood loss and transfusion reduction in TKA

J Knee Surg. 2018 Jan;31(1):56-67

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Aprotinin Aminocaproic Acid Blood Loss IA-TXA Placebo Reduction Replacement Revision TKA Transfusion Trasylol - Hide

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IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective

J Arthroplasty. 2017 Jan;32(1):37-42

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Aesculap Tranexamic Acid IV-IA TXA Navigated TKA Saline - Hide

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Topical TXA reduces transfusion and blood loss in THA compared to placebo

J Arthroplasty. 2014 Dec;29(12):2452-6

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Bone Femur Head Arthritis Blood Loss IA-TXA Placebo Saline Tranexamic Transfusion - Hide

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OARSI 2016: Efficacy of intramuscular corticosteroid injection vs. placebo for hip OA

RCT Osteoarthritis Lower Extremity Hip Muscle Gluteus Arthritis Pain Stiffness Corticosteroid Injection IM Intramuscular Injection Placebo Injection - Hide

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Assessment of IV, IA, and oral tranaexamic acid safety in total joint arthroplasty

J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023

Meta-analysis Arthroplasty Lower Extremity Hip Control IA Intraarticular Tranexamic Acid Intravenous Tranexamic Acid Intravenous TXA IV Oral Tranexamic Acid Oral TXA Placebo - Hide

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Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss IA TXA Induction Of Anaesthesia IV TXA Saline - Hide

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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Higher OMERACT-OARSI response rate following IA-HA injection vs steroid or placebo

Single-Dose IA ropivacaine reduces pain up to 8 hours post arthroscopic knee surgery

Comparison for IA corticosteroid versus saline injection following lavage for knee OA

IA ketorolac has no significant analgesic effect relative to placebo for post-knee arthroscopy pain

Addition of IA steroid injection to exercise not efficacious for knee OA inflammation

Safety and efficacy of IA bupivacaine for pain management after total joint arthroplasty

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Efficacy of joint lavage and/or IA CS injection in knee OA treatment; 2x2 factorial trial

IA bupivacaine and morphine reduces pain in arthroscopic knee surgery compared to placebo

Similar changes in clinical & radiographic results after 2 years with IA steroid vs saline

IA-TXA effective compared to placebo for blood loss and transfusion reduction in TKA

IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective

Topical TXA reduces transfusion and blood loss in THA compared to placebo

OARSI 2016: Efficacy of intramuscular corticosteroid injection vs. placebo for hip OA

Assessment of IV, IA, and oral tranaexamic acid safety in total joint arthroplasty

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

OARSI 2016: IA 20mg & 40mg extended-release triamcinolone acetonide vs placebo for knee OA

IA glucocorticioid not associated with decrease in synovitis when compared to IA saline for knee OA

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