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Multi-injection HA appears to be more effective than single-injection HA versus saline for knee OA

BMC Musculoskelet Disord. 2017 Dec 21;18(1):542

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Ferring HA Hyaluronic Acid Injections Placebo Injection Placebo Saline Single Injection - Hide

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IA-HA injection as adjunct to microfracture surgery for osteochondral lesions of the talus

Knee Surg Sports Traumatol Arthrosc. 2016 Apr;24(4):1243-9

RCT Foot & Ankle Lesion Lower Extremity Bone Talus Seikagaku Artz Injections HA Injection Hyaluronic Acid IA-HA Microfracture Surgery MRI - Hide

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Comparison of combined hyaluronic acid (HA) and corticosteroid vs. HA alone injection for knee OA

Exp Ther Med. 2018 Sep;16(3):1928-1934. doi: 10.3892/etm.2018.6371

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Injection - Hide

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ISAKOS 2015: PRP has better pain and function at 6 months than HA in knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Injection HA PRP - Hide

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Mannitol addition to HA improves early post-injection outcomes compared to HA alone for knee OA

J Med Assoc Thai. 2016 Oct;99(10):1094-101

RCT Osteoarthritis Lower Extremity Knee Arthritis TRB Chemedica Diclofenac Mannitol HA Single Intraarticular Injection Sodium Hyaluronate - Hide

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Efficacy of hyaluronic acid versus steroid injection for patients with trigger finger

Arch Phys Med Rehabil. 2015 Dec;96(12):2120-7

RCT Hand & Wrist Finger Trigger Finger Upper Extremity Injections Steroid Injection HA Hyaluronic Acid Ultrasound-Guided - Hide

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OARSI 2016: Allogenic mesenchymal precursor cells + hyaluronan injection after ACL repair

RCT Trauma Joint Ligament Hyaluronan Allogeneic Anterior Cruciate HA Reconstruction Single Injection - Hide

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PRP + HA Injection vs. PRP Alone and HA Alone for Grade II-III Knee Osteoarthritis

Adv Orthop. 2023 01-Mar;():. 10.1155/2023/1868943

RCT Osteoarthritis Appendicular Lower Extremity Knee Joint Tibiofemoral Orthovisc Viscosupplementation Platelet-Rich Plasma (PRP) Platelet-Rich Plasma (PRP) Hyaluronic Acid (HA) Biologic Biologic Regen Lab, Switzerland Regen Lab, Switzerland Regen Lab, Switzerland Regen Lab, Switzerland RegenKit BCT Cellular Matrix A-CP-HA Cellular Matrix A-CP-HA - Hide

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HA injections effective in improving pain & function in patients with knee osteoarthritis

Clin Rheumatol. 2005 Aug;24(4):336-41. Epub 2004 Dec 14

RCT Osteoarthritis Lower Extremity Knee Arthritis Cartilage Pain Hylan HA Injections MRI Placebo - Hide

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PRP injection versus HA or saline injection in knee osteoarthritis treatment

Arthroscopy. 2017 Mar;33(3):659-670

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Pain HA Hyaluronic Acid Injections Platelet-Rich Plasma Injections PRP Injection Reduction Saline Injections - Hide

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Knee OA: Significant decrease in proprioception error after three HA vs saline injections

J Back Musculoskelet Rehabil. 2009;22(1):1-9.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Biodex Wyeth Hylan Hyaluronan Injections HA Placebo Proprioception Saline - Hide

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HA injections successful in improving pain and function in knee osteoarthritis patients

The Pain Clinic, Vol. 15, No. 4, pp. 459–466 (2003)

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Hylan Injections HA Physical Therapy Program - Hide

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Effect of joint biomarkers on outcome in knee OA treatment with HA and CS indeterminate

J Orthop Sci. 2010 Jan;15(1):51-6. doi: 10.1007/s00776-009-1421-0. Epub 2010 Feb 12

RCT Osteoarthritis Lower Extremity Knee Arthritis Hyaluronan Dexamethasone Injection Corticosteroid HA Sodium Hyaluronate - Hide

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HA injection beneficial in knee OA with meniscus tears after arthroscopy

Am J Orthop (Belle Mead NJ). 2009 Dec;38(12):612-6

RCT Osteoarthritis Lower Extremity Knee Joint Meniscus Arthritis Tear Tears Aventis Sanofi Arthroscopy Injections HA Molecular Weight Sodium Hyaluronate - Hide

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Efficacy and safety of five weekly HA vs placebo injections in the treatment of knee OA

J Rheumatol. 2004 Apr;31(4):775-82.

RCT Osteoarthritis Lower Extremity Knee Arthritis Seikagaku Artz Hyaluronan HA Phosphate Placebo Injections - Hide

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No significant difference in effect on cartilage volume between HA vs placebo injection

Clin Exp Pharmacol 2012, 2:2

RCT Osteoarthritis Women Lower Extremity Knee Arthritis Cartilage Injections HA MRI Placebo Sodium Hyaluronate - Hide

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Effective pain relief with intraaarticular ketorolac/hyaluronic acid in cases of knee OA

J Back Musculoskelet Rehabil. 2011;24(1):31-8

RCT Osteoarthritis Women Lower Extremity Knee Arthritis Inflammation Pain Ketorolac Hyaluronic Acid IA HA Injections - Hide

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Efficacy of platelet rich plasma, HA, and combined therapy in patients with hip OA

Am J Sports Med. 2016 Mar;44(3):664-71

RCT Osteoarthritis Lower Extremity Hip Arthritis Pain Fidia Injections HA Hyaluronic Acid Platelet Rich Plasma - Hide

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HA injections improve knee OA symptoms and may exert a 1-year carry-over effect

Ann Rheum Dis. 2011 Nov;70(11):1957-62.

RCT Osteoarthritis Lower Extremity Knee Arthritis Tedec Meiji Farma Injections HA Hyaluronic Acid Placebo - Hide

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Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy

Knee Surg Sports Traumatol Arthrosc. 2018 Mar;26(3):903-911

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Chugai Pharmaceutical Injections Control High-Dose HA Hyaluronic Acid Low-Dose Reduction - Hide

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Multi-injection HA appears to be more effective than single-injection HA versus saline for knee OA

IA-HA injection as adjunct to microfracture surgery for osteochondral lesions of the talus

Comparison of combined hyaluronic acid (HA) and corticosteroid vs. HA alone injection for knee OA

ISAKOS 2015: PRP has better pain and function at 6 months than HA in knee OA

Mannitol addition to HA improves early post-injection outcomes compared to HA alone for knee OA

Efficacy of hyaluronic acid versus steroid injection for patients with trigger finger

OARSI 2016: Allogenic mesenchymal precursor cells + hyaluronan injection after ACL repair

PRP + HA Injection vs. PRP Alone and HA Alone for Grade II-III Knee Osteoarthritis

HA injections effective in improving pain & function in patients with knee osteoarthritis

PRP injection versus HA or saline injection in knee osteoarthritis treatment

Knee OA: Significant decrease in proprioception error after three HA vs saline injections

HA injections successful in improving pain and function in knee osteoarthritis patients

Effect of joint biomarkers on outcome in knee OA treatment with HA and CS indeterminate

HA injection beneficial in knee OA with meniscus tears after arthroscopy

Efficacy and safety of five weekly HA vs placebo injections in the treatment of knee OA

No significant difference in effect on cartilage volume between HA vs placebo injection

Effective pain relief with intraaarticular ketorolac/hyaluronic acid in cases of knee OA

Efficacy of platelet rich plasma, HA, and combined therapy in patients with hip OA

HA injections improve knee OA symptoms and may exert a 1-year carry-over effect

Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy

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