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Osteoarthritis
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis.
Inflammopharmacology. 2024 01-Jun;():. 10.1007/s10787-024-01460-9

Osteoarthritis

This study has been identified as potentially high impact. OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself. Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone. This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
N Engl J Med. 2006 Feb 23;354(8):795-808

Osteoarthritis

This study has been identified as potentially high impact. OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself. Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone. This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.

Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT)

This report has been verified by one or more authors of the original publication.

Ann Rheum Dis. 2017 May 22. pii: annrheumdis-2016-210860. doi: 10.1136/annrheumdis-2016-210860. [Epub ahead of print]

Osteoarthritis
Chondroitin sulfate plus glucosamine sulfate does not show superiority over placebo in a randomized, double blind, placebo-controlled clinical trial in patients with knee osteoarthritis

Osteoarthritis
In a two-year double-blind randomized controlled multicenter study, chondroitin sulfate was significantly superior to celecoxib at reducing cartilage loss with similar efficacy at reducing disease symptoms in knee osteoarthritis patients

Osteoarthritis
Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study

This report has been verified by one or more authors of the original publication.

J Sci Food Agric. 2012 Mar 15;92(4):862-9. doi: 10.1002/jsfa.4660. Epub 2011 Oct 3

General Orthopaedics
Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study

This report has been verified by one or more authors of the original publication.

Osteoarthritis Cartilage. 2012 Jul;20(7):622-9. Epub 2012 Mar 30.

Osteoarthritis
Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: a randomized, double-blind, placebo-controlled pilot study using MRI
Clin Rheumatol. 2012 Sep;31(9):1347-57. doi: 10.1007/s10067-012-2022-4. Epub 2012 Jun 23