Nico Piuzzi reflects on a path that carried him from Buenos Aires to the Cleveland Clinic, blending early interests in engineering, medicine, and public service. He describes a career shaped by arthroplasty, biologics, and an evolving vision of regenerative engineering, where data-driven personalization, predictive modeling, and multidisciplinary collaboration form the core of his current research. Beyond advancing osteoarthritis phenotyping and tackling periprosthetic infection, he emphasizes global knowledge exchange and the shared evolution of orthopedic innovation. Despite an intense academic portfolio, he attributes his balance and energy to family, time outdoors, and moments that keep him grounded.