In this episode of the OrthoJOE Podcast, hosts Mo Bhandari and Marc Swiontkowski sit down with Dr. Nicolas Piuzzi, the newly appointed Executive Editor of JBJS and Vice Chair of Research at the Cleveland Clinic. The conversation delves into Dr. Piuzzi,’s journey from Buenos Aires to a leading role in U.S. orthopedics, his passion for data-driven, personalized orthopedic care, and his groundbreaking work in AI, osteoarthritis, and infection research. With reflections on global disparities in care and the future of innovation in arthroplasty, this episode offers a dynamic blend of clinical insight, research vision, and personal inspiration.