The article describes a novel minimally invasive lumbar fusion technique that uses artificial intelligence (AI) and 3D printing to create patient-specific interbody devices tailored to an individual’s spinal anatomy. Traditional off-the-shelf fusion implants come in standard sizes that may not fit unique vertebral surfaces, potentially reducing stability and increasing complications such as implant subsidence. In the featured case, a CT scan was processed with AI to plan optimal spinal alignment and generate a 3D model of the patient’s lumbar spine. Custom implants were then 3D printed to match the patient’s bone contours and surgical goals, supporting better nerve decompression and spinal alignment than could be achieved with standard cages. This personalized approach aims to improve fusion outcomes and reduce the likelihood of future surgeries.