Osseointegration in the femur or tibia may significantly improve mobility and quality of life for patients with limb loss. This technique involves anchoring a prosthetic implant directly to bone, eliminating the need for traditional socket-based prostheses that can cause discomfort, skin irritation, and limited mobility. Clinical findings indicate that patients undergoing osseointegration may experience improved prosthetic control, enhanced functional performance, and greater overall satisfaction compared with conventional prosthetic approaches. By creating a stable mechanical connection between the implant and skeleton, osseointegration may allow more natural load transfer and improved proprioception. These results highlight the potential of bone-anchored prosthetic systems to enhance rehabilitation outcomes and restore function in individuals with lower-limb amputation.