OE Original: A Guide to Different Methods of Randomization
November 28, 2022
OE Original: A Guide to Different Methods of Randomization
Authored By: Selina Bains, Yaping Chang, Ellen Scholl, Sushmitha Pallapothu, Steve Phillips and Mohit Bhandari on Behalf of OrthoEvidence.
Highlights
- Randomization of participants is an important component of clinical trials to ensure the production of robust results.
- A variety of methods of randomization exist to account for factors such as sample size and covariate factors.
- Trials with small or large sample sizes without any covariates can use simple and block randomization respectively, whereas trials with covariates must use other methods depending on the type of covariate and how participants are enrolled.
Indicated by its name, this is the simplest form of randomization that is based on a single sequence of random assignments (Kang et al., 2008). Methods such as flipping a coin or rolling a die determines the assignment of participants to the treatment or control groups. For example, if there are two groups, a control and a treatment group, researchers can flip a coin where “heads” assigns participants to the control and “tails” assigns participants to the treatment group ...
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