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Assessing the efficacy of topical ketoprofen versus active- and placebo-comparators for knee OA
September 2017
Assessing the efficacy of topical ketoprofen versus active- and placebo-comparators for knee OA
Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis
Rheumatology (Oxford). 2013 Jul;52(7):1303-12Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
1399 patients with symptomatic knee osteoarthritis were randomized to either topical ketoprofen 50mg, topical ketoprofen 100mg, 2.2g or 4.4g of ketoprofen-free vehicle control, oral celecoxib 100mg, or oral placebo. Patients were assessed over 12 weeks of treatment for efficacy on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and safety using the incidence of adverse ...
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