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Meta-analysis
ACE Report #9611
Ace Report Cover Arthroplasty

Efficacy and safety of newer anticoagulants vs enoxaparin for thromboprophylaxis after TJA


Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

Safety and Efficacy of New Anticoagulants for the Prevention of Venous Thromboembolism After Hip and Knee Arthroplasty: A Meta-Analysis

J Arthroplasty. 2017 Feb;32(2):645-652

Contributing Authors: H Lin BT Venker BR Ganti ED Lee RM Nunley BF Gage

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Synopsis

18 randomized controlled trials were included in this meta-analysis evaluating the efficacy and safety of newer anticoagulants compared to enoxaparin in total knee and total hip arthroplasty. Anticoagulants evaluated included apixaban, dabigatran, fondaparinux, rivaroxaban, and edoxaban. The only newer anticoagulant which failed to demonstrate a significant reduction in VTE incidence relative to e...

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