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Intravenous TXA prior to tourniquet inflation more efficacious compared to later timepoints
November 2017
Intravenous TXA prior to tourniquet inflation more efficacious compared to later timepoints
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
The Efficacy Comparison of Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty at Different Dosage Time
J Arthroplasty. 2017 Jan;32(1):33-36Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
180 patients undergoing total knee arthroplasty were included in this trial to evaluate the effect that timing of tranexamic acid administration has on blood loss. Patients were randomized to receive 30mg/kg of tranexamic acid infused intravenously 15 minutes before tourniquet inflation, 15 min after tourniquet inflation, at tourniquet deflation, or to a control that did not receive tranexamic aci...
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