Zoledronic Acid, alendronate, and risedronate reduce vertebral, nonvertebral, and hip fracture

Study Type:Meta analysis

OE Level Evidence:1

Journal Level of Evidence:N/A

Comparative efficacy of bisphosphonates in short-term fracture prevention for primary osteoporosis: a systematic review with network meta-analyses

Osteoporos Int. 2016 Nov;27(11):3289-3300

Contributing Authors: X Ma J Zhou T Wang S Zhai

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Synopsis

36 randomized controlled trials were included in this network meta-analysis to evaluate the comparative efficacy of different bisphosphonates in the management of osteoporosis. Nine different bisphosphonates were assessed in the included studies, with direct and indirect comparisons evaluated for vertebral fracture, nonvertebral fracture, hip fracture, wrist fracture, and any fracture. Zoledronic ...