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Greater BMD increase with denosumab vs ZOL in patients switching from oral bisphosponates
January 2017
Greater BMD increase with denosumab vs ZOL in patients switching from oral bisphosponates
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Denosumab or Zoledronic Acid in Postmenopausal Women With Osteoporosis Previously Treated With Oral Bisphosphonates
J Clin Endocrinol Metab. 2016 Aug;101(8):3163-70Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
643 postmenopausal women with osteoporosis who had used oral bisphosphonate for a minimum of 2 years were randomized to either subcutaneous injections of denosumab 60mg - one at baseline and another at 6 months - or intravenous injection of zoledronic acid 5mg. The purpose of this study was to evaluate if denosumab offered noninferior or superior efficacy and safety to zoledronic acid for increasi...
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