Similar 15-year clinical outcome and failure rate between ACI and microfracture

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

A Randomized Multicenter Trial Comparing Autologous Chondrocyte Implantation with Microfracture: Long-Term Follow-up at 14 to 15 Years

J Bone Joint Surg Am. 2016 Aug 17;98(16):1332-9

Contributing Authors: G Knutsen JO Drogset L Engebretsen T Grontvedt TC Ludvigsen S Loken E Solheim T Strand O Johansen

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OE EXCLUSIVE

Synopsis

80 patients with an isolated knee cartilage lesion were randomized to undergo either autologous chondrocyte implantation (ACI) or microfracture (MFx). The purpose of this study was to compare clinical outcome measures and rate of failure (defined as a need for a secondary surgery due to symptom return) between groups over a 15-year follow-up. The rate of radiographic osteoarthritis development was...