Combined IV & topical TXA reduces blood loss and transfusion rate in THA
Tranexamic Acid Administration in Primary Total Hip Arthroplasty: A Randomized Controlled Trial of Intravenous Combined with Topical Versus Single-Dose Intravenous AdministrationJ Bone Joint Surg Am. 2016 Jun 15;98(12):983-91
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150 patients scheduled for primary unilateral total hip arthroplasty were randomized to one of three groups: a combined intravenous (IV) and topical tranexamic acid (TXA) protocol, IV TXA alone with topical placebo administration, or intravenous and topical placebo administration. The purpose of this study was to determine if the combined administration protocol demonstrated significantly greater ...
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