Comparison of risedronate, alendronate, zoledronate, and ibandronate in those with low BMD

Study Type:Meta analysis

OE Level Evidence:2

Journal Level of Evidence:N/A

Clinical effectiveness of bisphosphonates for the prevention of fragility fractures: A systematic review and network meta-analysis

Bone. 2016 Aug;89:52-8

Contributing Authors: J Sanderson M Martyn-St James J Stevens E Goka R Wong F Campbell P Selby N Gittoes S Davis

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here

Synopsis

A total of 27 randomized controlled trials were included in this network meta-analysis investigating the comparative efficacies of bisphosphonates - including alendronate, ibandronate, risedronate, and zoledronic acid - versus placebo or control in patients with low bone mineral density. All studied drugs demonstrated significant effects on vertebral fracture incidence and bone mineral density of ...