Comparison of risedronate, alendronate, zoledronate, and ibandronate in those with low BMD

How to Cite

OrthoEvidence. Comparison of risedronate, alendronate, zoledronate, and ibandronate in those with low BMD. ACE Report. 2016;5(9):39. Available from: https://myorthoevidene.com/AceReport/Report/9096

Study Type:Meta analysis

OE Level Evidence:2

Journal Level of Evidence:N/A

Clinical effectiveness of bisphosphonates for the prevention of fragility fractures: A systematic review and network meta-analysis

Bone. 2016 Aug;89:52-8

Contributing Authors: J Sanderson M Martyn-St James J Stevens E Goka R Wong F Campbell P Selby N Gittoes S Davis

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Synopsis

A total of 27 randomized controlled trials were included in this network meta-analysis investigating the comparative efficacies of bisphosphonates - including alendronate, ibandronate, risedronate, and zoledronic acid - versus placebo or control in patients with low bone mineral density. All studied drugs demonstrated significant effects on vertebral fracture incidence and bone mineral density of ...